Improve labeling of Active Neurons with Npas4 over cFos
Npas4 is an optimally-tunned, pure marker of neuronal activity unlike cFos & other IEGs
Overview
Introducing Npas4
cFos expression is induced by neuronal activity and many other non-related factors
Npas4 protein expression provides a pure marker of neuronal activity
Our anti-Npas4 recombinant monoclonal antibody can help you avoid ambiguous results
Why
Npas4 Background
GPCR-mediated elevations in cAMP, neurotrophins and other paracrine factors all drive cFos expression in neurons and non-neuronal cells
Npas4 is unique among IEG products in that expression is neuron-specific, has faster kinetics and is tuned exquisitely to Ca2+ signaling downstream of neuronal activity
Specificity
Antibody Validation
Our monoclonal antibody was raised against a large Npas4 protein fragment and selected among 100’s of clones for specificity as demonstrated by complete loss of reactivity in npas4 KO mice
Validated in many diverse applications in multiple species
Dr. Emily Johnson
Neuroscience Researcher, Brain Institute
Universal Tissue Clearing Kit
Clear and stain an extensive range of tissues, including mouse brain, lung, liver, spinal cord, and more using your preferred antibodies
Browse tools from our partner
Neuronal Activity Tissue Clearing Kit
Whole-brain measurement of recent changes in neuronal activity for systems-level insights into genetic, pharmacological, and behavioral treatments using Translucence Biosystems' validated Npas4 antibody and Synaptic Systems' cFos antibody